Nox2-deficient Tregs improve heart transplant outcomes via their increased graft recruitment and enhanced potency

Nox2 is a ROS-generating enzyme, deficiency of which increases suppression by Tregs in vitro and in an in vivo model of cardiac remodeling. As Tregs have emerged as a candidate therapy in autoimmunity and transplantation, we hypothesized that Nox2 deficiency in Tregs in recipient mice may improve ou...

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Detalles Bibliográficos
Autores principales: Trevelin, Silvia C., Zampetaki, Anna, Sawyer, Greta, Ivetic, Aleksandar, Brewer, Alison C., Smyth, Lesley Ann, Marelli-Berg, Federica, Köchl, Robert, Lechler, Robert I., Shah, Ajay M., Lombardi, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492330/
https://www.ncbi.nlm.nih.gov/pubmed/34375309
http://dx.doi.org/10.1172/jci.insight.149301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492330/
https://www.ncbi.nlm.nih.gov/pubmed/34375309
http://dx.doi.org/10.1172/jci.insight.149301

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