TGF-β1 protein trap AVID200 beneficially affects hematopoiesis and bone marrow fibrosis in myelofibrosis

Myelofibrosis (MF) is a progressive chronic myeloproliferative neoplasm characterized by hyperactivation of JAK/STAT signaling and dysregulation of the transcription factor GATA1 in megakaryocytes (MKs). TGF-β plays a pivotal role in the pathobiology of MF by promoting BM fibrosis and collagen depos...

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Detalles Bibliográficos
Autores principales: Varricchio, Lilian, Iancu-Rubin, Camelia, Upadhyaya, Bhaskar, Zingariello, Maria, Martelli, Fabrizio, Verachi, Paola, Clementelli, Cara, Denis, Jean-Francois, Rahman, Adeeb H., Tremblay, Gilles, Mascarenhas, John, Mesa, Ruben A., O’Connor-McCourt, Maureen, Migliaccio, Anna Rita, Hoffman, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492354/
https://www.ncbi.nlm.nih.gov/pubmed/34383713
http://dx.doi.org/10.1172/jci.insight.145651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492354/
https://www.ncbi.nlm.nih.gov/pubmed/34383713
http://dx.doi.org/10.1172/jci.insight.145651

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