Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration

Haematopoietic stem cells (HSCs) are normally quiescent, but have evolved mechanisms to respond to stress. Here, we evaluate haematopoietic regeneration induced by chemotherapy. We detect robust chromatin reorganization followed by increased transcription of transposable elements (TEs) during early...

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Detalles Bibliográficos
Autores principales: Clapes, Thomas, Polyzou, Aikaterini, Prater, Pia, Sagar, Morales-Hernández, Antonio, Ferrarini, Mariana Galvao, Kehrer, Natalie, Lefkopoulos, Stylianos, Bergo, Veronica, Hummel, Barbara, Obier, Nadine, Maticzka, Daniel, Bridgeman, Anne, Herman, Josip S., Ilik, Ibrahim, Klaeylé, Lhéanna, Rehwinkel, Jan, McKinney-Freeman, Shannon, Backofen, Rolf, Akhtar, Asifa, Cabezas-Wallscheid, Nina, Sawarkar, Ritwick, Rebollo, Rita, Grün, Dominic, Trompouki, Eirini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492473/
https://www.ncbi.nlm.nih.gov/pubmed/34253898
http://dx.doi.org/10.1038/s41556-021-00707-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492473/
https://www.ncbi.nlm.nih.gov/pubmed/34253898
http://dx.doi.org/10.1038/s41556-021-00707-9

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