T Cell–Mediated Antitumor Immunity Cooperatively Induced By TGFβR1 Antagonism and Gemcitabine Counteracts Reformation of the Stromal Barrier in Pancreatic Cancer

The desmoplastic stroma of pancreatic cancers forms a physical barrier that impedes intratumoral drug delivery. Attempts to modulate the desmoplastic stroma to increase delivery of administered chemotherapy have not shown positive clinical results thus far, and preclinical reports in which chemother...

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Detalles Bibliográficos
Autores principales: Li, Dandan, Schaub, Nicholas, Guerin, Theresa M., Bapiro, Tashinga E., Richards, Frances M., Chen, Vicky, Talsania, Keyur, Kumar, Parimal, Gilbert, Debra J., Schlomer, Jerome J., Kim, Seong-Jin, Sorber, Rebecca, Teper, Yaroslav, Bautista, Wendy, Palena, Claudia, Ock, Chan-Young, Jodrell, Duncan I., Pate, Nathan, Mehta, Monika, Zhao, Yongmei, Kozlov, Serguei, Rudloff, Udo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Small Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492543/
https://www.ncbi.nlm.nih.gov/pubmed/34376576
http://dx.doi.org/10.1158/1535-7163.MCT-20-0620

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492543/
https://www.ncbi.nlm.nih.gov/pubmed/34376576
http://dx.doi.org/10.1158/1535-7163.MCT-20-0620

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