Concentration of Na(+)-taurocholate-cotransporting polypeptide expressed after in vitro-transcribed mRNA transfection determines susceptibility of hepatoma cells for hepatitis B virus

Infection of hepatocytes by hepatitis B virus (HBV) depends on surface expression of its receptor Na(+)-taurocholate-cotransporting polypeptide (NTCP), but sufficient NTCP expression is lacking in most cell lines. NTCP can be introduced by plasmid transfection or transduction by viral vectors to ren...

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Detalles Bibliográficos
Autores principales: Oswald, Andreas, Chakraborty, Anindita, Ni, Yi, Wettengel, Jochen M., Urban, Stephan, Protzer, Ulrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492621/
https://www.ncbi.nlm.nih.gov/pubmed/34611272
http://dx.doi.org/10.1038/s41598-021-99263-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492621/
https://www.ncbi.nlm.nih.gov/pubmed/34611272
http://dx.doi.org/10.1038/s41598-021-99263-3

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