Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1

Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent histone deacetylase that plays diverse physiological roles. However, little is known about the regulation of SIRT1 activity. Here, we show that phospholipase D2 (PLD2), but not PLD1, selectively interacts with SIRT1 and increases the...

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Detalles Bibliográficos
Autores principales: Lee, Hyesung, Jung, Taek-Yeol, Lim, Seong Hun, Choi, Eun Ju, Lee, Jinu, Min, Do Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492672/
https://www.ncbi.nlm.nih.gov/pubmed/34471223
http://dx.doi.org/10.1038/s12276-021-00659-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492672/
https://www.ncbi.nlm.nih.gov/pubmed/34471223
http://dx.doi.org/10.1038/s12276-021-00659-y

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