Genomic and transcriptomic analyses reveal a tandem amplification unit of 11 genes and mutations in mismatch repair genes in methotrexate-resistant HT-29 cells

DHFR gene amplification is commonly present in methotrexate (MTX)-resistant colon cancer cells and acute lymphoblastic leukemia. In this study, we proposed an integrative framework to characterize the amplified region by using a combination of single-molecule real-time sequencing, next-generation op...

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Detalles Bibliográficos
Autores principales: Kim, Ahreum, Shin, Jong-Yeon, Seo, Jeong-Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492700/
https://www.ncbi.nlm.nih.gov/pubmed/34521988
http://dx.doi.org/10.1038/s12276-021-00668-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492700/
https://www.ncbi.nlm.nih.gov/pubmed/34521988
http://dx.doi.org/10.1038/s12276-021-00668-x

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