The protective effect of the PDE-4 inhibitor rolipram on intracerebral haemorrhage is associated with the cAMP/AMPK/SIRT1 pathway

Rolipram specifically inhibits phosphodiesterase (PDE) 4, thereby preventing inactivation of the intracellular second messenger cyclic adenosine monophosphate (cAMP). Rolipram has been shown to play a neuroprotective role in some central nervous system (CNS) diseases. However, the role of PDE4 and t...

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Detalles Bibliográficos
Autores principales: Dong, Xiao-Liu, Wang, Yan-Hui, Xu, Jing, Zhang, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492710/
https://www.ncbi.nlm.nih.gov/pubmed/34611179
http://dx.doi.org/10.1038/s41598-021-98743-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492710/
https://www.ncbi.nlm.nih.gov/pubmed/34611179
http://dx.doi.org/10.1038/s41598-021-98743-w

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