Cargando…

MRTF-A-NF-κB/p65 axis-mediated PDL1 transcription and expression contributes to immune evasion of non-small-cell lung cancer via TGF-β

PD-L1 is abnormally regulated in many cancers and is critical for immune escape. Fully understanding the regulation of PD-L1 expression is vital for improving the clinical efficacy of relevant anticancer agents. TGF-β plays an important role in the low reactivity of PD-1/PD-L1 antibody immunotherapy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Du, Fu, Qi, Xin, Zhang, Aotong, Sui, Fanfan, Wang, Xuemin, Proud, Christopher G., Lin, Cunzhi, Fan, Xinglong, Li, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492728/ https://www.ncbi.nlm.nih.gov/pubmed/34548615 http://dx.doi.org/10.1038/s12276-021-00670-3

Ejemplares similares

RNF182 induces p65 ubiquitination to affect PDL1 transcription and suppress immune evasion in lung adenocarcinoma
por: Zeng, Xingdu, et al.
Publicado: (2023)

A cAbl-MRTF-A Feedback Loop Contributes to Hepatic Stellate Cell Activation
por: Lu, Yunjie, et al.
Publicado: (2019)

An MRTF-A–ZEB1–IRF9 axis contributes to fibroblast–myofibroblast transition and renal fibrosis
por: Zhao, Qianwen, et al.
Publicado: (2023)

Oxidative Stress Enhances the TGF-β2-RhoA-MRTF-A/B Axis in Cells Entering Endothelial-Mesenchymal Transition
por: Sobierajska, Katarzyna, et al.
Publicado: (2022)

Cyclophilin A (CypA) Interacts with NF-κB Subunit, p65/RelA, and Contributes to NF-κB Activation Signaling
por: Sun, Shan, et al.
Publicado: (2014)

Hypoxia and P. gingivalis Synergistically Induce HIF-1 and NF-κB Activation in PDL Cells and Periodontal Diseases
por: Gölz, L., et al.
Publicado: (2015)

Suppression of NF-κB Activity: A Viral Immune Evasion Mechanism
por: Deng, Liyao, et al.
Publicado: (2018)

HDAC6 Regulates the MRTF-A/SRF Axis and Vascular Smooth Muscle Cell Plasticity
por: Zhang, Mengxue, et al.
Publicado: (2018)

NF-κB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell death
por: Lim, Chuan Bian, et al.
Publicado: (2012)

An MRTF-A–Sp1–PDE5 Axis Mediates Angiotensin-II-Induced Cardiomyocyte Hypertrophy
por: Wu, Teng, et al.
Publicado: (2020)

Gene regulation and deregulation by MAL/MRTF coactivators
por: Posern, G
Publicado: (2009)

MRTF: Basic Biology and Role in Kidney Disease
por: Miranda, Maria Zena, et al.
Publicado: (2021)

Cell Adhesion and Shape Regulate TGF-Beta1-Induced Epithelial-Myofibroblast Transition via MRTF-A Signaling
por: O’Connor, Joseph W., et al.
Publicado: (2013)

Mechanisms of NF-κB p65 and strategies for therapeutic manipulation
por: Giridharan, Sivagami, et al.
Publicado: (2018)

The Expression of SOCS and NF-ϰB p65 in Hypopharyngeal Carcinoma
por: FENG, Shu, et al.
Publicado: (2018)

Strontium Ranelate Ameliorates Intervertebral Disc Degeneration via Regulating TGF-β1/NF-κB Axis
por: Sun, Ruping, et al.
Publicado: (2023)

Corrigendum: An MRTF-A–Sp1–PDE5 Axis Mediates Angiotensin-II-Induced Cardiomyocyte Hypertrophy
por: Wu, Teng, et al.
Publicado: (2021)

Synthesis of Novel Peptide Dendrimers PDL-GB2 and PDL-G2
por: Yunzhu, Lin, et al.
Publicado: (2015)

Epidermal p65/NF-κB signalling is essential for skin carcinogenesis
por: Kim, Chun, et al.
Publicado: (2014)

Serum NF-κBp65, TLR4 as Biomarker for Diagnosis of Preeclampsia
por: Litang, Zhao, et al.
Publicado: (2017)

PDLIM1 inhibits NF-κB-mediated inflammatory signaling by sequestering the p65 subunit of NF-κB in the cytoplasm
por: Ono, Rumiko, et al.
Publicado: (2015)

PTRF/Cavin-1 as a Novel RNA-Binding Protein Expedites the NF-κB/PD-L1 Axis by Stabilizing lncRNA NEAT1, Contributing to Tumorigenesis and Immune Evasion in Glioblastoma
por: Yi, Kaikai, et al.
Publicado: (2022)

Modulating Myofibroblastic Differentiation of Fibroblasts through Actin-MRTF Signaling Axis by Micropatterned Surfaces for Suppressed Implant-Induced Fibrosis
por: Han, Weiju, et al.
Publicado: (2023)

Circulating miR-103a-3p contributes to angiotensin II-induced renal inflammation and fibrosis via a SNRK/NF-κB/p65 regulatory axis
por: Lu, Qiulun, et al.
Publicado: (2019)

Puerarin Alleviates UUO-Induced Inflammation and Fibrosis by Regulating the NF-κB P65/STAT3 and TGFβ1/Smads Signaling Pathways
por: Wang, Jingyu, et al.
Publicado: (2021)

The levels of NF-κB p50 and NF-κB p65 play a role in thyroid carcinoma malignancy in vivo
por: Le, Fei, et al.
Publicado: (2018)

Epstein–Barr virus envelope glycoprotein 110 inhibits NF-κB activation by interacting with NF-κB subunit p65
por: Cai, Mingsheng, et al.
Publicado: (2023)

Cyclin-Dependent Kinase 6 Phosphorylates NF-κB P65 at Serine 536 and Contributes to the Regulation of Inflammatory Gene Expression
por: Buss, Holger, et al.
Publicado: (2012)

UBR5 promotes tumor immune evasion through enhancing IFN-γ-induced PDL1 transcription in triple negative breast cancer
por: Wu, Bingbing, et al.
Publicado: (2022)

Profibrotic epithelial phenotype: a central role for MRTF and TAZ
por: Bialik, Janne Folke, et al.
Publicado: (2019)

MRTF specifies a muscle-like contractile module in Porifera
por: Colgren, J., et al.
Publicado: (2022)

Two Modes of Transcriptional Activation at Native Promoters by NF-κB p65
por: van Essen, Dominic, et al.
Publicado: (2009)

NF-κB p65 directs sex-specific neuroprotection in human neurons
por: Ruiz-Perera, Lucia M., et al.
Publicado: (2018)

Stress-dependent phosphorylation of myocardin-related transcription factor A (MRTF-A) by the p38(MAPK)/MK2 axis
por: Ronkina, Natalia, et al.
Publicado: (2016)

Genistein alleviates chronic vascular inflammatory response via the miR-21/NF-κB p65 axis in lipopolysaccharide-treated mice
por: Xie, Xiaolin, et al.
Publicado: (2021)

Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3
por: Speight, Pam, et al.
Publicado: (2016)

NF-κB inhibitor with Temozolomide results in significant apoptosis in glioblastoma via the NF-κB(p65) and actin cytoskeleton regulatory pathways
por: Avci, Naze G., et al.
Publicado: (2020)

Dihydromyricetin Reverses Thioacetamide-Induced Liver Fibrosis Through Inhibiting NF-κB-Mediated Inflammation and TGF-β1-Regulated of PI3K/Akt Signaling Pathway
por: Zhao, Yingchun, et al.
Publicado: (2021)

Canonical NF-κB p65, but Not p105, Contributes to IL-1β-Induced IL-8 Expression in Cardiac Fibroblasts
por: Mizuno, Masashi, et al.
Publicado: (2022)

Publisher Correction: Circulating miR-103a-3p contributes to angiotensin II-induced renal inflammation and fibrosis via a SNRK/NF-κB/p65 regulatory axis
por: Lu, Qiulun, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_k9lf2mh7qi0ido06db68hkbqms