An unusual nicotinamide derivative, 4-pyridone-3-carboxamide ribonucleoside (4PYR), is a novel endothelial toxin and oncometabolite

Our recent studies identified a novel pathway of nicotinamide metabolism that involves 4-pyridone-3-carboxamide-1-β-D-ribonucleoside (4PYR) and demonstrated its endothelial cytotoxic effect. This study tested the effects of 4PYR and its metabolites in experimental models of breast cancer. Mice were...

Descripción completa

Detalles Bibliográficos
Autores principales: Mierzejewska, Paulina, Kunc, Michal, Zabielska-Kaczorowska, Magdalena Agnieszka, Kutryb-Zajac, Barbara, Pelikant-Malecka, Iwona, Braczko, Alicja, Jablonska, Patrycja, Romaszko, Pawel, Koszalka, Patrycja, Szade, Jolanta, Smolenski, Ryszard Tomasz, Slominska, Ewa Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492732/
https://www.ncbi.nlm.nih.gov/pubmed/34580423
http://dx.doi.org/10.1038/s12276-021-00669-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492732/
https://www.ncbi.nlm.nih.gov/pubmed/34580423
http://dx.doi.org/10.1038/s12276-021-00669-w

Ejemplares similares