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An unusual nicotinamide derivative, 4-pyridone-3-carboxamide ribonucleoside (4PYR), is a novel endothelial toxin and oncometabolite

Our recent studies identified a novel pathway of nicotinamide metabolism that involves 4-pyridone-3-carboxamide-1-β-D-ribonucleoside (4PYR) and demonstrated its endothelial cytotoxic effect. This study tested the effects of 4PYR and its metabolites in experimental models of breast cancer. Mice were...

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Detalles Bibliográficos
Autores principales:	Mierzejewska, Paulina, Kunc, Michal, Zabielska-Kaczorowska, Magdalena Agnieszka, Kutryb-Zajac, Barbara, Pelikant-Malecka, Iwona, Braczko, Alicja, Jablonska, Patrycja, Romaszko, Pawel, Koszalka, Patrycja, Szade, Jolanta, Smolenski, Ryszard Tomasz, Slominska, Ewa Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492732/ https://www.ncbi.nlm.nih.gov/pubmed/34580423 http://dx.doi.org/10.1038/s12276-021-00669-w

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