The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGFβ signalling in cardiac fibroblasts

Fibrosis accompanies most heart diseases and is associated with adverse patient outcomes. Transforming growth factor (TGF)β drives extracellular matrix remodelling and fibrosis in the failing heart. Some members of the ADAMTSL (a disintegrin-like and metalloproteinase domain with thrombospondin type...

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Detalles Bibliográficos
Autores principales: Rypdal, Karoline B., Erusappan, Pugazendhi M., Melleby, A. Olav, Seifert, Deborah E., Palmero, Sheryl, Strand, Mari E., Tønnessen, Theis, Dahl, Christen P., Almaas, Vibeke, Hubmacher, Dirk, Apte, Suneel S., Christensen, Geir, Lunde, Ida G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492753/
https://www.ncbi.nlm.nih.gov/pubmed/34611183
http://dx.doi.org/10.1038/s41598-021-99032-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492753/
https://www.ncbi.nlm.nih.gov/pubmed/34611183
http://dx.doi.org/10.1038/s41598-021-99032-2

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