APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline

Population-based studies reveal that apolipoprotein E (APOE) ε4 gene allele is closely associated with late-life depression (LLD). However, its exact role and underlying mechanism remain obscure. The current study found that aged apoE4-targeted replacement (TR) mice displayed obvious depression-like...

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Detalles Bibliográficos
Autores principales: Fang, Wenting, Xiao, Naian, Zeng, Guirong, Bi, Daode, Dai, Xiaoman, Mi, Xue, Ye, Qinyong, Chen, Xiaochun, Zhang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492798/
https://www.ncbi.nlm.nih.gov/pubmed/34611141
http://dx.doi.org/10.1038/s41398-021-01631-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492798/
https://www.ncbi.nlm.nih.gov/pubmed/34611141
http://dx.doi.org/10.1038/s41398-021-01631-0

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