Regulation of TDP-43 phosphorylation in aging and disease

Insoluble inclusions of phosphorylated TDP-43 occur in disease-affected neurons of most patients with amyotrophic lateral sclerosis (ALS) and about half of patients with frontotemporal lobar degeneration (FTLD-TDP). Phosphorylated TDP-43 potentiates a number of neurotoxic effects including reduced l...

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Detalles Bibliográficos
Autores principales: Eck, Randall J., Kraemer, Brian C., Liachko, Nicole F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492835/
https://www.ncbi.nlm.nih.gov/pubmed/34032984
http://dx.doi.org/10.1007/s11357-021-00383-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492835/
https://www.ncbi.nlm.nih.gov/pubmed/34032984
http://dx.doi.org/10.1007/s11357-021-00383-5

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