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Regulation of TDP-43 phosphorylation in aging and disease

Insoluble inclusions of phosphorylated TDP-43 occur in disease-affected neurons of most patients with amyotrophic lateral sclerosis (ALS) and about half of patients with frontotemporal lobar degeneration (FTLD-TDP). Phosphorylated TDP-43 potentiates a number of neurotoxic effects including reduced l...

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Detalles Bibliográficos
Autores principales:	Eck, Randall J., Kraemer, Brian C., Liachko, Nicole F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492835/ https://www.ncbi.nlm.nih.gov/pubmed/34032984 http://dx.doi.org/10.1007/s11357-021-00383-5

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