Gambogic acid and gambogenic acid induce a thiol-dependent heat shock response and disrupt the interaction between HSP90 and HSF1 or HSF2

Cancer cells rely on heat shock proteins (HSPs) for growth and survival. Especially HSP90 has multiple client proteins and plays a critical role in malignant transformation, and therefore different types of HSP90 inhibitors are being developed. The bioactive natural compound gambogic acid (GB) is a...

Descripción completa

Detalles Bibliográficos
Autores principales: Pesonen, Linda, Svartsjö, Sally, Bäck, Viktor, de Thonel, Aurélie, Mezger, Valérie, Sabéran-Djoneidi, Délara, Roos-Mattjus, Pia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492855/
https://www.ncbi.nlm.nih.gov/pubmed/34331200
http://dx.doi.org/10.1007/s12192-021-01222-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492855/
https://www.ncbi.nlm.nih.gov/pubmed/34331200
http://dx.doi.org/10.1007/s12192-021-01222-4

Ejemplares similares