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Augmentation of the heat shock axis during exceptional longevity in Ames dwarf mice
How the heat shock axis, repair pathways, and proteostasis impact the rate of aging is not fully understood. Recent reports indicate that normal aging leads to a 50% change in several regulatory elements of the heat shock axis. Most notably is the age-dependent enhancement of inhibitory signals asso...
Autores principales: | Trivedi, Rachana, Knopf, Bailey, Tripathi, Jitendra Kumar, Rakoczy, Shar, Manocha, Gunjan D., Brown-Borg, Holly, Jurivich, Donald A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492860/ https://www.ncbi.nlm.nih.gov/pubmed/33846884 http://dx.doi.org/10.1007/s11357-021-00362-w |
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