Adeno-Associated Virus-Mediated Gain-of-Function mPCSK9 Expression in the Mouse Induces Hypercholesterolemia, Monocytosis, Neutrophilia, and a Hypercoagulative State

Hypercholesterolemia has previously been induced in the mouse by a single intravenous injection of adeno-associated virus (AAV)-based vector harboring gain-of-function pro-protein convertase subtilisin/kexin type 9. Despite the recent emergence of the PCSK9-AAV model, the profile of hematological an...

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Detalles Bibliográficos
Autores principales: Louloudis, Georgios, Ambrosini, Samuele, Paneni, Francesco, Camici, Giovanni G., Benke, Dietmar, Klohs, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492965/
https://www.ncbi.nlm.nih.gov/pubmed/34631822
http://dx.doi.org/10.3389/fcvm.2021.718741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492965/
https://www.ncbi.nlm.nih.gov/pubmed/34631822
http://dx.doi.org/10.3389/fcvm.2021.718741

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