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Adeno-Associated Virus-Mediated Gain-of-Function mPCSK9 Expression in the Mouse Induces Hypercholesterolemia, Monocytosis, Neutrophilia, and a Hypercoagulative State

Hypercholesterolemia has previously been induced in the mouse by a single intravenous injection of adeno-associated virus (AAV)-based vector harboring gain-of-function pro-protein convertase subtilisin/kexin type 9. Despite the recent emergence of the PCSK9-AAV model, the profile of hematological an...

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Detalles Bibliográficos
Autores principales:	Louloudis, Georgios, Ambrosini, Samuele, Paneni, Francesco, Camici, Giovanni G., Benke, Dietmar, Klohs, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492965/ https://www.ncbi.nlm.nih.gov/pubmed/34631822 http://dx.doi.org/10.3389/fcvm.2021.718741

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