Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico, In Vitro, and SAR Studies

Guided by the structural optimization principle and the promising anticancer effect of the quinoxaline nucleus, a new series of novel HDAC inhibitors were designed and synthesized. The synthesized compounds were designed to bear the reported pharmacophoric features of the HDAC inhibitors in addition...

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Detalles Bibliográficos
Autores principales: Ma, Chao, Taghour, Mohammed S., Belal, Amany, Mehany, Ahmed B. M., Mostafa, Naglaa, Nabeeh, Ahmed, Eissa, Ibrahim H., Al-Karmalawy, Ahmed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493129/
https://www.ncbi.nlm.nih.gov/pubmed/34631658
http://dx.doi.org/10.3389/fchem.2021.725135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493129/
https://www.ncbi.nlm.nih.gov/pubmed/34631658
http://dx.doi.org/10.3389/fchem.2021.725135

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