Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243

Human Ether-à-go-go (hERG) channels contribute to cardiac repolarization, and inherited variants or drug block are associated with long QT syndrome type 2 (LQTS2) and arrhythmia. Therefore, hERG activator compounds present a therapeutic opportunity for targeted treatment of LQTS. However, a limiting...

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Detalles Bibliográficos
Autores principales: Kemp, Jacob M., Whittaker, Dominic G., Venkateshappa, Ravichandra, Pang, ZhaoKai, Johal, Raj, Sergeev, Valentine, Tibbits, Glen F., Mirams, Gary R., Claydon, Thomas W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493834/
https://www.ncbi.nlm.nih.gov/pubmed/34398210
http://dx.doi.org/10.1085/jgp.202112923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493834/
https://www.ncbi.nlm.nih.gov/pubmed/34398210
http://dx.doi.org/10.1085/jgp.202112923

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