Sheep models of F508del and G542X cystic fibrosis mutations show cellular responses to human therapeutics

Cystic Fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. The F508del and G542X are the most common mutations found in US patients, accounting for 86.4% and 4.6% of all mutations, respectively. The F508del causes deletion of the phenylal...

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Detalles Bibliográficos
Autores principales: Viotti Perisse, Iuri, Fan, Zhiqiang, Van Wettere, Arnaud, Liu, Ying, Leir, Shih‐Hsing, Keim, Jacob, Regouski, Misha, Wilson, Michael D., Cholewa, Kelly M., Mansbach, Sara N., Kelley, Thomas J., Wang, Zhongde, Harris, Ann, White, Kenneth L., Polejaeva, Irina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493969/
https://www.ncbi.nlm.nih.gov/pubmed/34632318
http://dx.doi.org/10.1096/fba.2021-00043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493969/
https://www.ncbi.nlm.nih.gov/pubmed/34632318
http://dx.doi.org/10.1096/fba.2021-00043

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