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Sheep models of F508del and G542X cystic fibrosis mutations show cellular responses to human therapeutics
Cystic Fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. The F508del and G542X are the most common mutations found in US patients, accounting for 86.4% and 4.6% of all mutations, respectively. The F508del causes deletion of the phenylal...
Autores principales: | Viotti Perisse, Iuri, Fan, Zhiqiang, Van Wettere, Arnaud, Liu, Ying, Leir, Shih‐Hsing, Keim, Jacob, Regouski, Misha, Wilson, Michael D., Cholewa, Kelly M., Mansbach, Sara N., Kelley, Thomas J., Wang, Zhongde, Harris, Ann, White, Kenneth L., Polejaeva, Irina A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493969/ https://www.ncbi.nlm.nih.gov/pubmed/34632318 http://dx.doi.org/10.1096/fba.2021-00043 |
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