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OX40‐targeted immune agonist antibodies induce potent antitumor immune responses without inducing liver damage in mice

Despite promising preclinical and clinical data demonstrating that immune agonist antibody immunotherapies (IAAs) such as αOX40 induce strong antitumor immune responses, clinical translation has been significantly hampered by the propensity of some IAAs to induce dose‐limiting and sometimes life‐thr...

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Detalles Bibliográficos
Autores principales: Tee, Yee C., Blake, Stephen J., Lynn, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493970/
https://www.ncbi.nlm.nih.gov/pubmed/34632317
http://dx.doi.org/10.1096/fba.2021-00039