A combination of solid-state NMR and MD simulations reveals the binding mode of a rhomboid protease inhibitor

Intramembrane proteolysis plays a fundamental role in many biological and pathological processes. Intramembrane proteases thus represent promising pharmacological targets, but few selective inhibitors have been identified. This is in contrast to their soluble counterparts, which are inhibited by man...

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Detalles Bibliográficos
Autores principales: Bohg, Claudia, Öster, Carl, Utesch, Tillmann, Bischoff, Susanne, Lange, Sascha, Shi, Chaowei, Sun, Han, Lange, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494044/
https://www.ncbi.nlm.nih.gov/pubmed/34703562
http://dx.doi.org/10.1039/d1sc02146j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494044/
https://www.ncbi.nlm.nih.gov/pubmed/34703562
http://dx.doi.org/10.1039/d1sc02146j

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