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A combination of solid-state NMR and MD simulations reveals the binding mode of a rhomboid protease inhibitor
Intramembrane proteolysis plays a fundamental role in many biological and pathological processes. Intramembrane proteases thus represent promising pharmacological targets, but few selective inhibitors have been identified. This is in contrast to their soluble counterparts, which are inhibited by man...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494044/ https://www.ncbi.nlm.nih.gov/pubmed/34703562 http://dx.doi.org/10.1039/d1sc02146j |