Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine–dependent interface: a model for KRAS oligomerization

KRAS forms transient dimers and higher-order multimers (nanoclusters) on the plasma membrane, which drive MAPK signaling and cell proliferation. KRAS is a frequently mutated oncogene, and while it is well known that the most prevalent mutation, G12D, impairs GTP hydrolysis, thereby increasing KRAS a...

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Detalles Bibliográficos
Autores principales: Lee, Ki-Young, Enomoto, Masahiro, Gebregiworgis, Teklab, Gasmi-Seabrook, Geneviève M. C., Ikura, Mitsuhiko, Marshall, Christopher B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494122/
https://www.ncbi.nlm.nih.gov/pubmed/34703570
http://dx.doi.org/10.1039/d1sc03484g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494122/
https://www.ncbi.nlm.nih.gov/pubmed/34703570
http://dx.doi.org/10.1039/d1sc03484g

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