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Systematic functional characterization of antisense eRNA of protocadherin α composite enhancer

Enhancers generate bidirectional noncoding enhancer RNAs (eRNAs) that may regulate gene expression. At present, the eRNA function remains enigmatic. Here, we report a 5′ capped antisense eRNA PEARL (Pcdh eRNA associated with R-loop formation) that is transcribed from the protocadherin (Pcdh) α HS5-1...

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Detalles Bibliográficos
Autores principales: Zhou, Yuxiao, Xu, Siyuan, Zhang, Mo, Wu, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494205/
https://www.ncbi.nlm.nih.gov/pubmed/34531317
http://dx.doi.org/10.1101/gad.348621.121