Polo-like kinase 2 inhibition reduces serine-129 phosphorylation of physiological nuclear alpha-synuclein but not of the aggregated alpha-synuclein

Accumulation of aggregated alpha-synuclein (α-syn) is believed to play a pivotal role in the pathophysiology of Parkinson’s disease (PD) and other synucleinopathies. As a key constituent of Lewy pathology, more than 90% of α-syn in Lewy bodies is phosphorylated at serine-129 (pS129) and hence, it is...

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Detalles Bibliográficos
Autores principales: Elfarrash, Sara, Jensen, Nanna Møller, Ferreira, Nelson, Schmidt, Sissel Ida, Gregersen, Emil, Vestergaard, Marie Vibeke, Nabavi, Sadegh, Meyer, Morten, Jensen, Poul Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494365/
https://www.ncbi.nlm.nih.gov/pubmed/34613964
http://dx.doi.org/10.1371/journal.pone.0252635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494365/
https://www.ncbi.nlm.nih.gov/pubmed/34613964
http://dx.doi.org/10.1371/journal.pone.0252635

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