Cosmc deficiency causes spontaneous autoimmunity by breaking B cell tolerance

Factors regulating the induction and development of B cell–mediated autoimmunity are not well understood. Here, we report that targeted deletion in murine B cells of X-linked Cosmc, encoding the chaperone required for expression of core 1 O-glycans, causes the spontaneous development of autoimmune p...

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Detalles Bibliográficos
Autores principales: Zeng, Junwei, Aryal, Rajindra P., Stavenhagen, Kathrin, Luo, Chi, Liu, Renyan, Wang, Xiaohui, Chen, Jiaxuan, Li, Hao, Matsumoto, Yasuyuki, Wang, Yingchun, Wang, Jianmei, Ju, Tongzhong, Cummings, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494437/
https://www.ncbi.nlm.nih.gov/pubmed/34613773
http://dx.doi.org/10.1126/sciadv.abg9118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494437/
https://www.ncbi.nlm.nih.gov/pubmed/34613773
http://dx.doi.org/10.1126/sciadv.abg9118

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