Cargando…

Cosmc deficiency causes spontaneous autoimmunity by breaking B cell tolerance

Factors regulating the induction and development of B cell–mediated autoimmunity are not well understood. Here, we report that targeted deletion in murine B cells of X-linked Cosmc, encoding the chaperone required for expression of core 1 O-glycans, causes the spontaneous development of autoimmune p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeng, Junwei, Aryal, Rajindra P., Stavenhagen, Kathrin, Luo, Chi, Liu, Renyan, Wang, Xiaohui, Chen, Jiaxuan, Li, Hao, Matsumoto, Yasuyuki, Wang, Yingchun, Wang, Jianmei, Ju, Tongzhong, Cummings, Richard D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494437/ https://www.ncbi.nlm.nih.gov/pubmed/34613773 http://dx.doi.org/10.1126/sciadv.abg9118

Ejemplares similares

Cosmc controls B cell homing
por: Zeng, Junwei, et al.
Publicado: (2020)

Regulation of protein O-glycosylation by the endoplasmic reticulum–localized molecular chaperone Cosmc
por: Ju, Tongzhong, et al.
Publicado: (2008)

Identification and characterization of circulating immune complexes in IgA nephropathy
por: Matsumoto, Yasuyuki, et al.
Publicado: (2022)

Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers
por: Sun, Xiaodong, et al.
Publicado: (2018)

Cosmc converter
por: Williams, Ruth
Publicado: (2006)

NAC1 modulates autoimmunity by suppressing regulatory T cell–mediated tolerance
por: Yang, Jin-Ming, et al.
Publicado: (2022)

lncRNA-GM targets Foxo1 to promote T cell–mediated autoimmunity
por: Chen, Yali, et al.
Publicado: (2022)

Requirement of WDR70 for POLE3-mediated DNA double-strand breaks repair
por: Mao, Xiaobing, et al.
Publicado: (2023)

Global lactylome reveals lactylation-dependent mechanisms underlying T(H)17 differentiation in experimental autoimmune uveitis
por: Fan, Wei, et al.
Publicado: (2023)

The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces
por: Glentis, Alexandros, et al.
Publicado: (2022)

Microglia promote autoimmune inflammation via the noncanonical NF-κB pathway
por: Jie, Zuliang, et al.
Publicado: (2021)

N-terminal signal peptides facilitate the engineering of PVC complex as a potent protein delivery system
por: Jiang, Feng, et al.
Publicado: (2022)

Regulation of autoimmune disease progression by Pik3ip1 through metabolic reprogramming in T cells and therapeutic implications
por: Xie, Wenqiang, et al.
Publicado: (2022)

Translational regulation of TFH cell differentiation and autoimmune pathogenesis
por: Patel, Preeyam S., et al.
Publicado: (2022)

Biochemical characterization of functional domains of the chaperone Cosmc
por: Hanes, Melinda S., et al.
Publicado: (2017)

A dominant function of LynB kinase in preventing autoimmunity
por: Brian, Ben F., et al.
Publicado: (2022)

Multi-tiered approach to detect autoimmune cross-reactivity of therapeutic T cell receptors
por: Ishii, Kazusa, et al.
Publicado: (2023)

Phosphofructokinase P fine-tunes T regulatory cell metabolism, function, and stability in systemic autoimmunity
por: Scherlinger, Marc, et al.
Publicado: (2022)

Base editor enables rational genome-scale functional screening for enhanced industrial phenotypes in Corynebacterium glutamicum
por: Liu, Ye, et al.
Publicado: (2022)

Endoreplication mediates cell size control via mechanochemical signaling from cell wall
por: Ma, Yuan, et al.
Publicado: (2022)

AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination
por: Tsukumo, Shin-ichi, et al.
Publicado: (2022)

Versatile ginsenoside Rg3 liposomes inhibit tumor metastasis by capturing circulating tumor cells and destroying metastatic niches
por: Xia, Jiaxuan, et al.
Publicado: (2022)

The deubiquitinases UBP12 and UBP13 integrate with the E3 ubiquitin ligase XBAT35.2 to modulate VPS23A stability in ABA signaling
por: Liu, Guangchao, et al.
Publicado: (2022)

Lactate induces vascular permeability via disruption of VE-cadherin in endothelial cells during sepsis
por: Yang, Kun, et al.
Publicado: (2022)

Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction
por: Fan, Min, et al.
Publicado: (2023)

Clinical PARP inhibitors allosterically induce PARP2 retention on DNA
por: Langelier, Marie-France, et al.
Publicado: (2023)

Primary specification of blastocyst trophectoderm by scRNA-seq: New insights into embryo implantation
por: Liu, Dandan, et al.
Publicado: (2022)

Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression
por: Liu, Chao, et al.
Publicado: (2023)

14-3-3-zeta mediates GLP-1 receptor agonist action to alter α cell proglucagon processing
por: Holter, Marlena M., et al.
Publicado: (2022)

Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis
por: Slonchak, Andrii, et al.
Publicado: (2022)

Precise CRISPR-Cas–mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells
por: Tran, Ngoc Tung, et al.
Publicado: (2022)

Canonical strigolactones are not the major determinant of tillering but important rhizospheric signals in rice
por: Ito, Shinsaku, et al.
Publicado: (2022)

Defective import of mitochondrial metabolic enzyme elicits ectopic metabolic stress
por: Nishio, Kazuya, et al.
Publicado: (2023)

A highly specific CRISPR-Cas12j nuclease enables allele-specific genome editing
por: Wang, Yao, et al.
Publicado: (2023)

Cosmc overexpression enhances malignancies in human colon cancer
por: Gao, Tianbo, et al.
Publicado: (2019)

A bispecific glycopeptide spatiotemporally regulates tumor microenvironment for inhibiting bladder cancer recurrence
por: An, Hong-Wei, et al.
Publicado: (2023)

Structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT
por: Han, Wenyu, et al.
Publicado: (2023)

m(6)A RNA demethylase AtALKBH9B promotes mobilization of a heat-activated long terminal repeat retrotransposon in Arabidopsis
por: Fan, Wenwen, et al.
Publicado: (2023)

Live attenuated virus vaccine protects against SARS-CoV-2 variants of concern B.1.1.7 (Alpha) and B.1.351 (Beta)
por: Trimpert, Jakob, et al.
Publicado: (2021)

PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma
por: Peng, Song, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_51ounsmhfn5br8em7am47g83ma