Cargando…
Prickle promotes the formation and maintenance of glutamatergic synapses by stabilizing the intercellular planar cell polarity complex
Whether there exists a common signaling mechanism that assembles all glutamatergic synapses is unknown. We show here that knocking out Prickle1 and Prickle2 reduced the formation of the PSD-95–positive glutamatergic synapses in the hippocampus and medial prefrontal cortex in postnatal development by...
Autores principales: | Ban, Yue, Yu, Ting, Feng, Bo, Lorenz, Charlotte, Wang, Xiaojia, Baker, Clayton, Zou, Yimin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494439/ https://www.ncbi.nlm.nih.gov/pubmed/34613779 http://dx.doi.org/10.1126/sciadv.abh2974 |
Ejemplares similares
-
Rapid Disruption of Dishevelled Activity Uncovers an Intercellular Role in Maintenance of Prickle in Core Planar Polarity Protein Complexes
por: Ressurreição, Margarida, et al.
Publicado: (2018) -
The core PCP protein Prickle2 regulates axon number and AIS maturation by binding to AnkG and modulating microtubule bundling
por: Dorrego-Rivas, Ana, et al.
Publicado: (2022) -
Planar cell polarity signaling components are a direct target of β-amyloid–associated degeneration of glutamatergic synapses
por: Feng, Bo, et al.
Publicado: (2021) -
Cell cortex regulation by the planar cell polarity protein Prickle1
por: Huang, Yunyun, et al.
Publicado: (2022) -
Prickle is phosphorylated by Nemo and targeted for degradation to maintain Prickle/Spiny-legs isoform balance during planar cell polarity establishment
por: Collu, Giovanna M., et al.
Publicado: (2018)