Metformin: a novel promising option for fertility preservation during cyclophosphamide-based chemotherapy

Cyclophosphamide (CP) could cause severe gonadotoxicity via imbalanced activation of primordial follicles through PI3K/AKT/mTOR activation. Whether metformin, a widely prescribed anti-diabetes agent with mTOR inhibitory effect, could preserve ovarian function against CP toxicity is unknown. Female C...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Chu-Chun, Chou, Chia-Hung, Yang, Yu-Shih, Ho, Hong-Nerng, Shun, Chia-Tung, Wen, Wen-Fen, Chen, Shee-Uan, Chen, Mei-Jou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494485/
https://www.ncbi.nlm.nih.gov/pubmed/33543290
http://dx.doi.org/10.1093/molehr/gaaa084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494485/
https://www.ncbi.nlm.nih.gov/pubmed/33543290
http://dx.doi.org/10.1093/molehr/gaaa084

Ejemplares similares