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Metformin: a novel promising option for fertility preservation during cyclophosphamide-based chemotherapy

Cyclophosphamide (CP) could cause severe gonadotoxicity via imbalanced activation of primordial follicles through PI3K/AKT/mTOR activation. Whether metformin, a widely prescribed anti-diabetes agent with mTOR inhibitory effect, could preserve ovarian function against CP toxicity is unknown. Female C...

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Detalles Bibliográficos
Autores principales:	Huang, Chu-Chun, Chou, Chia-Hung, Yang, Yu-Shih, Ho, Hong-Nerng, Shun, Chia-Tung, Wen, Wen-Fen, Chen, Shee-Uan, Chen, Mei-Jou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494485/ https://www.ncbi.nlm.nih.gov/pubmed/33543290 http://dx.doi.org/10.1093/molehr/gaaa084

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