Increased biosynthesis of acetyl-CoA in the yeast Saccharomyces cerevisiae by overexpression of a deregulated pantothenate kinase gene and engineering of the coenzyme A biosynthetic pathway

Coenzyme A (CoA) and its derivatives such as acetyl-CoA are essential metabolites for several biosynthetic reactions. In the yeast S. cerevisiae, five enzymes (encoded by essential genes CAB1-CAB5; coenzyme A biosynthesis) are required to perform CoA biosynthesis from pantothenate, cysteine, and ATP...

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Detalles Bibliográficos
Autores principales: Olzhausen, Judith, Grigat, Mathias, Seifert, Larissa, Ulbricht, Tom, Schüller, Hans-Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Applied Genetics and Molecular Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494682/
https://www.ncbi.nlm.nih.gov/pubmed/34491400
http://dx.doi.org/10.1007/s00253-021-11523-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494682/
https://www.ncbi.nlm.nih.gov/pubmed/34491400
http://dx.doi.org/10.1007/s00253-021-11523-4

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