PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages

Human genetic studies have linked rare coding variants in microglial genes, such as TREM2, and more recently PLCG2 to Alzheimer’s disease (AD) pathology. The P522R variant in PLCG2 has been shown to confer protection for AD and to result in a subtle increase in enzymatic activity. PLCγ2 is a key com...

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Detalles Bibliográficos
Autores principales: Obst, Juliane, Hall-Roberts, Hazel L., Smith, Thomas B., Kreuzer, Mira, Magno, Lorenza, Di Daniel, Elena, Davis, John B., Mead, Emma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494732/
https://www.ncbi.nlm.nih.gov/pubmed/34615897
http://dx.doi.org/10.1038/s41598-021-96144-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494732/
https://www.ncbi.nlm.nih.gov/pubmed/34615897
http://dx.doi.org/10.1038/s41598-021-96144-7

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