Calibrated rare variant genetic risk scores for complex disease prediction using large exome sequence repositories

Rare variants are collectively numerous and may underlie a considerable proportion of complex disease risk. However, identifying genuine rare variant associations is challenging due to small effect sizes, presence of technical artefacts, and heterogeneity in population structure. We hypothesize that...

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Detalles Bibliográficos
Autores principales: Lali, Ricky, Chong, Michael, Omidi, Arghavan, Mohammadi-Shemirani, Pedrum, Le, Ann, Cui, Edward, Paré, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494733/
https://www.ncbi.nlm.nih.gov/pubmed/34615865
http://dx.doi.org/10.1038/s41467-021-26114-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494733/
https://www.ncbi.nlm.nih.gov/pubmed/34615865
http://dx.doi.org/10.1038/s41467-021-26114-0

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