Cytosolic protein delivery using pH-responsive, charge-reversible lipid nanoparticles

Although proteins have attractive features as biopharmaceuticals, the difficulty in delivering them into the cell interior limits their applicability. Lipid nanoparticles (LNPs) are a promising class of delivery vehicles. When designing a protein delivery system based on LNPs, the major challenges i...

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Detalles Bibliográficos
Autores principales: Hirai, Yusuke, Hirose, Hisaaki, Imanishi, Miki, Asai, Tomohiro, Futaki, Shiroh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494842/
https://www.ncbi.nlm.nih.gov/pubmed/34615928
http://dx.doi.org/10.1038/s41598-021-99180-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494842/
https://www.ncbi.nlm.nih.gov/pubmed/34615928
http://dx.doi.org/10.1038/s41598-021-99180-5

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