The GPR171 pathway suppresses T cell activation and limits antitumor immunity

The recently identified G-protein-coupled receptor GPR171 and its ligand BigLEN are thought to regulate food uptake and anxiety. Though GPR171 is commonly used as a T cell signature gene in transcriptomic studies, its potential role in T cell immunity has not been explored. Here we show that GPR171...

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Detalles Bibliográficos
Autores principales: Fujiwara, Yuki, Torphy, Robert J., Sun, Yi, Miller, Emily N., Ho, Felix, Borcherding, Nicholas, Wu, Tuoqi, Torres, Raul M., Zhang, Weizhou, Schulick, Richard D., Zhu, Yuwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494883/
https://www.ncbi.nlm.nih.gov/pubmed/34615877
http://dx.doi.org/10.1038/s41467-021-26135-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494883/
https://www.ncbi.nlm.nih.gov/pubmed/34615877
http://dx.doi.org/10.1038/s41467-021-26135-9

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