Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound

Malignant cells display an increased sensitivity towards drugs that reduce the function of the ubiquitin-proteasome system (UPS), which is the primary proteolytic system for destruction of aberrant proteins. Here, we report on the discovery of the bioactivatable compound CBK77, which causes an irrev...

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Detalles Bibliográficos
Autores principales: Giovannucci, Tatiana A., Salomons, Florian A., Haraldsson, Martin, Elfman, Lotta H. M., Wickström, Malin, Young, Patrick, Lundbäck, Thomas, Eirich, Jürgen, Altun, Mikael, Jafari, Rozbeh, Gustavsson, Anna-Lena, Johnsen, John Inge, Dantuma, Nico P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494907/
https://www.ncbi.nlm.nih.gov/pubmed/34615851
http://dx.doi.org/10.1038/s41419-021-04191-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494907/
https://www.ncbi.nlm.nih.gov/pubmed/34615851
http://dx.doi.org/10.1038/s41419-021-04191-9

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