Tcf1 and Lef1 provide constant supervision to mature CD8(+) T cell identity and function by organizing genomic architecture

T cell identity is established during thymic development, but how it is maintained in the periphery remains unknown. Here we show that ablating Tcf1 and Lef1 transcription factors in mature CD8(+) T cells aberrantly induces genes from non-T cell lineages. Using high-throughput chromosome-conformatio...

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Detalles Bibliográficos
Autores principales: Shan, Qiang, Li, Xiang, Chen, Xia, Zeng, Zhouhao, Zhu, Shaoqi, Gai, Kexin, Peng, Weiqun, Xue, Hai-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494933/
https://www.ncbi.nlm.nih.gov/pubmed/34615872
http://dx.doi.org/10.1038/s41467-021-26159-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494933/
https://www.ncbi.nlm.nih.gov/pubmed/34615872
http://dx.doi.org/10.1038/s41467-021-26159-1

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