Cargando…
Tcf1 and Lef1 provide constant supervision to mature CD8(+) T cell identity and function by organizing genomic architecture
T cell identity is established during thymic development, but how it is maintained in the periphery remains unknown. Here we show that ablating Tcf1 and Lef1 transcription factors in mature CD8(+) T cells aberrantly induces genes from non-T cell lineages. Using high-throughput chromosome-conformatio...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494933/ https://www.ncbi.nlm.nih.gov/pubmed/34615872 http://dx.doi.org/10.1038/s41467-021-26159-1 |