Midbrain organoids with an SNCA gene triplication model key features of synucleinopathy

SNCA, the first gene associated with Parkinson’s disease, encodes the α-synuclein protein, the predominant component within pathological inclusions termed Lewy bodies. The presence of Lewy bodies is one of the classical hallmarks found in the brain of patients with Parkinson’s disease, and Lewy bodi...

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Detalles Bibliográficos
Autores principales: Mohamed, Nguyen-Vi, Sirois, Julien, Ramamurthy, Janani, Mathur, Meghna, Lépine, Paula, Deneault, Eric, Maussion, Gilles, Nicouleau, Michael, Chen, Carol X -Q, Abdian, Narges, Soubannier, Vincent, Cai, Eddie, Nami, Harris, Thomas, Rhalena A, Wen, Dingke, Tabatabaei, Mahdieh, Beitel, Lenore K, Singh Dolt, Karamjit, Karamchandani, Jason, Stratton, Jo Anne, Kunath, Tilo, Fon, Edward A, Durcan, Thomas M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495137/
https://www.ncbi.nlm.nih.gov/pubmed/34632384
http://dx.doi.org/10.1093/braincomms/fcab223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495137/
https://www.ncbi.nlm.nih.gov/pubmed/34632384
http://dx.doi.org/10.1093/braincomms/fcab223

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