NUDT15 c.415C>T Polymorphism Predicts 6-MP Induced Early Myelotoxicity in Patients with Acute Lymphoblastic Leukemia Undergoing Maintenance Therapy

PURPOSE: Severe myelosuppression in patients with acute lymphoblastic leukemia (ALL) undergoing 6-MP-based maintenance therapy is attributed to TPMT gene polymorphisms, which is rare in Asian populations. This study aims to evaluate the role of selected polymorphisms in NUDT15, ITPA, and MRP4 genes...

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Detalles Bibliográficos
Autores principales: Pai, Aswin Anand, Mohan, Ajith, Benjamin, Esther Sathya Bama, Illangeswaran, Raveen Stephen Stallon, Xavier Raj, Infencia, Janet, Nancy Beryl, Arunachalam, Arun Kumar, Kavitha, M L, Kulkarni, Uday, Devasia, Anup J, Fouzia, N A, Abraham, Aby, Srivastava, Alok, George, Biju, Mathews, Vikram, Korula, Anu, Balasubramanian, Poonkuzhali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495143/
https://www.ncbi.nlm.nih.gov/pubmed/34629890
http://dx.doi.org/10.2147/PGPM.S325813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495143/
https://www.ncbi.nlm.nih.gov/pubmed/34629890
http://dx.doi.org/10.2147/PGPM.S325813

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