Assessment of Mosaicism and Detection of Cryptic Alleles in CRISPR/Cas9-Engineered Neurofibromatosis Type 1 and TP53 Mutant Porcine Models Reveals Overlooked Challenges in Precision Modeling of Human Diseases

Genome editing in pigs has been made efficient, practical, and economically viable by the CRISPR/Cas9 platform, representing a promising new era in translational modeling of human disease for research and preclinical development of therapies and devices. Porcine embryo microinjection provides a univ...

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Detalles Bibliográficos
Autores principales: Rubinstein, Clifford Dustin, McLean, Dalton T., Lehman, Brent P., Meudt, Jennifer J., Schomberg, Dominic T., Krentz, Kathy J., Reichert, Jamie L., Meyer, Mark B., Adams, Marie, Konsitzke, Charles M., Shanmuganayagam, Dhanansayan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495252/
https://www.ncbi.nlm.nih.gov/pubmed/34630515
http://dx.doi.org/10.3389/fgene.2021.721045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495252/
https://www.ncbi.nlm.nih.gov/pubmed/34630515
http://dx.doi.org/10.3389/fgene.2021.721045

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