Cycloastragenol and Astragaloside IV activate telomerase and protect nucleus pulposus cells against high glucose-induced senescence and apoptosis

In diabetes-induced intervertebral disc degeneration (Db-IVDD), senescence and apoptosis of nucleus pulposus cells (NPCs) are major contributing factors. Telomere attrition and telomerase downregulation are some of the main reasons for senescence and eventual apoptosis. The derivatives of the Chines...

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Detalles Bibliográficos
Autores principales: Hong, Haofeng, Xiao, Jian, Guo, Quanquan, Du, Jinhui, Jiang, Zhichen, Lu, Sisi, Zhang, Hongyuan, Zhang, Xiaolei, Wang, Xiangyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495541/
https://www.ncbi.nlm.nih.gov/pubmed/34630680
http://dx.doi.org/10.3892/etm.2021.10761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495541/
https://www.ncbi.nlm.nih.gov/pubmed/34630680
http://dx.doi.org/10.3892/etm.2021.10761

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