Stable maintenance of the Mre11-Rad50-Nbs1 complex is sufficient to restore the DNA double-strand break response in cells lacking RecQL4 helicase activity

The proper cellular response to DNA double-strand breaks (DSBs) is critical for maintaining the integrity of the genome. RecQL4, a DNA helicase of which mutations are associated with Rothmund–Thomson syndrome (RTS), is required for the DNA DSB response. However, the mechanism by which RecQL4 perform...

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Detalles Bibliográficos
Autores principales: Kim, Hyunsup, Choi, Hyemin, Im, Jun-Sub, Park, Soon-Young, Shin, Gwangsu, Yoo, Jung-Ho, Kim, Gyungmin, Lee, Joon-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495703/
https://www.ncbi.nlm.nih.gov/pubmed/34473993
http://dx.doi.org/10.1016/j.jbc.2021.101148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495703/
https://www.ncbi.nlm.nih.gov/pubmed/34473993
http://dx.doi.org/10.1016/j.jbc.2021.101148

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