Intercellular transfer of mitochondrial DNA carrying metastasis-enhancing pathogenic mutations from high- to low-metastatic tumor cells and stromal cells via extracellular vesicles

BACKGROUND: Mitochondrial DNA (mtDNA) carrying certain pathogenic mutations or single nucleotide variants (SNVs) enhances the invasion and metastasis of tumor cells, and some of these mutations are homoplasmic in tumor cells and even in tumor tissues. On the other hand, intercellular transfer of mit...

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Detalles Bibliográficos
Autores principales: Takenaga, Keizo, Koshikawa, Nobuko, Nagase, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496074/
https://www.ncbi.nlm.nih.gov/pubmed/34615464
http://dx.doi.org/10.1186/s12860-021-00391-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496074/
https://www.ncbi.nlm.nih.gov/pubmed/34615464
http://dx.doi.org/10.1186/s12860-021-00391-5

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