Macrocyclic peptides as allosteric inhibitors of nicotinamide N-methyltransferase (NNMT)

Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide to form 1-methylnicotinamide (MNA) using S-adenosyl-l-methionine (SAM) as the methyl donor. The complexity of the role of NNMT in healthy and disease states is slowly being elucidated and provides an indication that NNMT may be an inter...

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Detalles Bibliográficos
Autores principales: van Haren, Matthijs J., Zhang, Yurui, Thijssen, Vito, Buijs, Ned, Gao, Yongzhi, Mateuszuk, Lukasz, Fedak, Filip A., Kij, Agnieszka, Campagna, Roberto, Sartini, Davide, Emanuelli, Monica, Chlopicki, Stefan, Jongkees, Seino A. K., Martin, Nathaniel I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496086/
https://www.ncbi.nlm.nih.gov/pubmed/34704059
http://dx.doi.org/10.1039/d1cb00134e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496086/
https://www.ncbi.nlm.nih.gov/pubmed/34704059
http://dx.doi.org/10.1039/d1cb00134e

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