The Type 2 Diabetes Factor Methylglyoxal Mediates Axon Initial Segment Shortening and Alters Neuronal Function at the Cellular and Network Levels

Recent evidence suggests that alteration of axon initial segment (AIS) geometry (i.e., length or location along the axon) contributes to CNS dysfunction in neurological diseases. For example, AIS length is shorter in the prefrontal cortex of type 2 diabetic mice with cognitive impairment. To determi...

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Detalles Bibliográficos
Autores principales: Griggs, Ryan B., Nguyen, Duc V. M., Yermakov, Leonid M., Jaber, Jeneane M., Shelby, Jennae N., Steinbrunner, Josef K., Miller, John A., Gonzalez-Islas, Carlos, Wenner, Peter, Susuki, Keiichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2021
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496204/
https://www.ncbi.nlm.nih.gov/pubmed/34531281
http://dx.doi.org/10.1523/ENEURO.0201-21.2021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496204/
https://www.ncbi.nlm.nih.gov/pubmed/34531281
http://dx.doi.org/10.1523/ENEURO.0201-21.2021

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